Epileptic activity arises from dysfunction of pathological neuronal network (epileptic network). Aim: to assess maintenance of epileptic network in between IEDs occurrence.We acquired simultaneous EEG-fMRI resting state in 10 drug-resistant focal epilepsy patients, having multifocal BOLD response and maximal t-value in the IED field. We compared results of functional connectivity (FC) before and after removing IEDs effect for two seed types: a 10mm-diameter sphere drawn in the BOLD map maximum and the epileptic component obtained by Indipendent component analysis. We evaluated the results in terms of mean t-value and the percentage of overlap between the FC maps.Mean t-value was significant lower after regressing out the IEDs at group level (p=0.008 for sphere; p=0.0004 for epileptic component). Overlap extent was 85%±12% and 87%±12% for the sphere and the epileptic component, respectively.Regions involved in a specific epileptic network show coherent oscillation independent of the occurrence of interictal activity. This could indicate the presence of epileptic activity invisible to the scalp-EEG or the presence of new and pathological resting state networks.Regions involved in a specific epileptic network show functional coupling independently of the occurrence of interictal activity as revealed on scalp EEG.