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Though it is now well established that T lymphocytes develop in the murine intestinal epithelium, many features of T lymphopoiesis occurring at this site remain controversial and poorly understood. One of the most contentious issues is whether all TcRαβ + iIEL subsets, characterized by the differential expression of CD4, CD8α and CD8β, develop in situ, as suggested by the analysis of athymic...
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