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The MHC class II molecules, expressed by antigen presenting cells, are heterodimers composed of an α and a β chain, which function to present processed antigen to helper T cells. The human MHC class II molecules, HLA-DR1 and HLA-DR3, crystallized not as monomers, but rather dimers of αβ heterodimers. The 'dimer of dimers' or 'superdimer' structure led to speculation that the binding of T-cell receptors...
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