We here report a three-fold elevation of dopamine D 4 -like sites in schizophrenia, using [ 3 H]nemonapride to measure dopamine D 2 and D 3 receptors and D 4 -like sites, and using [ 1 2 5 I]epidepride to measure D 2 and D 3 sites in ten control and nine schizophrenia post-mortem brain putamen tissues. This result differs from a recent report which did not detect significant D 4 -like sites in control or schizophrenia putamen (Reynolds and Mason, 1995, Eur. J. Pharmacol. 281, R5). The present finding agrees with other reports wherein an elevation in D 4 -like sites was found in schizophrenia, using [ 3 H]nemonapride for D 2 , D 3 and D 4 -like sites, but [ 3 H]raclopride for D 2 and D 3 sites. The nature of these D 4 -like sites is not known.