A multicenter U.S. registry study was designed to evaluate elective stenting using the GR II ( R) stent in small vessels (diameter >2.1 mm and <3.0 mm) with lesions <30 mm long. Demographics: 262 patients, 64% male, 30% diabetic, 45% high cholesterol, 65% multivessel disease, 38% prior MI, 22% prior CABG. Lesions: reference vessel diameter 2.6 +/- 0.3 mm (45% =<2.5 mm), lesion length 14 +/- 8 mm (39% =<15 mm), diameter stenosis 75 +/- 21%, 62% class B2 and C, 44% diffuse disease, 29% moderate/severe proximal tortuosity.Results: Stents (20 or 40 mm long) were successfully implanted in 258 patients (98.5%, 1.4 stents/lesion); average residual stenosis was -2 +/- 2%. Post-procedure, patients received ticlopidine and aspirin. Acute thrombosis (<24 hours) occurred in 1.6%, subacute thrombosis in 2.4%. Cardiac events are shown in the table. Multivariate predictors of TLR at 31-180 days included female gender (p = 0.05) and number of stents (p = 0.07).Conclusions: Despite complex, long, and tortuous lesions, elective stenting of small vessels resulted in high success, excellent early outcome, and a 6-month symptom-driven TLR rate superior to the historic rate with angioplasty alone.