The Hellenic plate boundary region, located in the collision zone between the Nubian/Arabian and Eurasian lithospheric plates, is one of the seismo-tectonically most active areas of Europe. During the last 15 years, GPS measurements have been used to determine the crustal motion in the area of Greece with the aim to better understand the geodynamical processes of this region. An extended reoccupation network covering whole Greece has been measured periodically in numerous GPS campaigns since the late eighties, and a continuous GPS network has been operated in the region of the Ionian Sea since 1995. In this paper, we present a new detailed high-quality solution of continuous and campaign-type measurements acquired between 1993 and 2003. During the GPS processing, a special effort was made to obtain consistent results with highest possible accuracies and reliabilities. Data of 54 mainly European IGS and EUREF sites were included in the GPS processing in order to obtain results which are internally consistent with the European kinematic field and order to allow for a regional interpretation. After an overview of the results of the IGS/EUREF sites, the results from more than 80 stations in Greece are presented in terms of velocities, time series, trajectories and strain rates. Previous geodetic, geological and seismological findings are generally confirmed and substantially refined. New important results include the observation of deformation zones to the north and to the south of the North Aegean Trough and in the West Hellenic arc region, arc-parallel extension of about 19 mm/yr along the Hellenic arc, and compression between the Ionian islands and the Greek mainland. Due to continuous long-term observations of 4–8 years, it was possible to extract height changes from the GPS time series. In Greece, we observe a differential subsidence of the order of 2 mm/yr between the northern and central Ionian islands across the Kefalonia fault zone. The differential subsidence of the central Ionian islands with respect to the northwestern Greek mainland amounts to 4 mm/yr.