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To explore the economic viability of N-of-1 trials for improving access to selected high cost medications in Australia. Cost and effectiveness estimates were derived from two N-of-1 trials conducted by The University of Queensland from 2003 to 2005—celecoxib versus sustained-release paracetamol for osteoarthritis in a general practice setting and gabapentin versus placebo for chronic neuropathic...
To assess the balance between costs and upper gastrointestinal (GI) side effects of treatment with celecoxib, nonsteroidal antiinflammatory drugs (NSAIDs) alone, NSAID plus misoprostol, NSAID plus histamine-2 receptor antagonist (H 2 RA), NSAID plus proton pump inhibitor (PPI), and Arthrotec in The Netherlands. A model was used to convene data from various sources on the probability of...
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