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Intramolecular hydrogen bonds directly involving fluorine atoms are important for pre-organizing the molecule in a defined conformation and for improving the cell permeability of a molecule. Several NMR observable parameters can be used for detecting these intramolecular hydrogen bonds. The two fluorine atoms of the molecule 2-chloro-6-fluoro-N-(4-fluoro-1-methyl-1H-indazol-3yl)benzamide, which is...
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