The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Corona phase molecular recognition (CoPhMoRe) is a phenomenon whereby a polymer or surfactant corona phase wrapped around a nanoparticle selectively recognizes a particular molecule. The method can potentially generate non-biological, synthetic molecular recognition sites, analogous to antibodies, for a broad range of biomedical applications, including new types of sensors, laboratory and clinical...
Reduced graphene oxide–iron oxide quantum dots (QDs) with intrinsic photoluminescent and superparamagnetic properties were synthesized through a green, hydrothermal method that simultaneously reduced and shattered graphene nanosheets to form the dots. The structure, morphology, properties and cell viability of these QDs were investigated. The QDs emitted violet light when excited at 320nm, possessed...
Graphene oxide (GO) has been harnessed in diverse biomedical applications such as drug delivery, biomolecule detection and enzymatic activity assay for a decade. In specific, optical biosensors have been developed based on the preferential binding of single stranded nucleic acid on GO and fluorescence quenching capability of GO. Recently, nano-size GO (NGO), which is smaller than micro-sized large...
Porous graphene oxide–poly(urea–formaldehyde) (GO–PUF) hybrid monolith was prepared by the in situ polycondensation of the urea–formaldehyde prepolymer solution in the presence of GO sheets and ammonium chloride. The amide groups in the residues of asparagine and glutamine in trypsin was allowed to condense with the residual N-hydroxymethyl groups of PUF in the monolith at low pH to fabricate bioreactors...
Activated carbon (AC) can be used for blood purification (hemoperfusion) to treat a range of conditions by direct perfusion of blood through an adsorbent column. The clinical effects of hemoperfusion relate to the AC adsorptive capacity, and any inflammatory response generated by direct blood contact. The use of a biocompatible coating minimizes side-effects but at the same time significantly reduces...
Pristine (as prepared) carbon nanotube (CNT) based substrates have been widely used to grow and interface neurons in culture. Nerve cells normally differentiate on CNTs and the synaptic networks, newly formed at the interface with this material, usually show an improved robustness in signal transfer. However manipulation of pristine CNTs is often prevented by their low dispersibility and tendency...
Cartilage as a tissue in the body possesses a low regenerative capacity and is extremely difficult to repair. Today, treatment of cartilage injury, degeneration and defects presents critical clinical challenges, yet none of the currently available cartilage treatments provides a perfect solution. Since natural cartilage extracellular matrix is a nanoscaled structure, the main objective of this study...
Prolonged therapeutic action over an extended period of time on single dose is vital in designing an ideal drug delivery system. Nanoparticle-based vehicles for drug delivery serves as an ideal technology, however, utilization of them remains controversial due to potential safety concerns and transient drug retention. Nanodiamonds (NDs), with excellent biocompatibility and diversity of potential conjugates,...
The development of efficient contrast agents for cell labelling coupled with powerful medical imaging techniques is of great interest for monitoring cell trafficking with potential clinical applications such as organ repair and regenerative medicine. In this paper, functionalised multi-walled carbon nanotubes (MWNTs) were engineered for cell labelling in T1-weighted MRI applications. These sophisticated...
The combination of different treatments in cancer therapy has drawn massive attention in the last decades due to its superior anticancer ability to single treatment. One of the most useful strategies to achieve this purpose is to design and construct efficient multifunctional nanoplatforms. Here we report our effort in development of carbon nanoparticles/doxorubicin@SiO2 nanocomposites and their application...
Graphene oxide foam (GOF) layers with thicknesses of ∼15–50μm and density of ∼10 graphene oxide (GO) sheets/μm were fabricated by precipitation of chemically exfoliated GO sheets in an aqueous suspension at ∼80°C under UV irradiation. Then, rolled GOFs with desirable scales were developed as electrically conductive 3D-scaffolds and applied in directional growth of neural fibers, through differentiation...
Textured surfaces with periodic topographical features and long-range order are highly attractive for directing cell-material interactions. They mimic physiological environments more accurately than planar surfaces and can fundamentally alter cell alignment, shape, gene expression, as well as multicellular organization into hierarchical tissue architectures. Here we demonstrate for the first time...
Nanomaterials have been extensively investigated for cancer drug delivery and imaging applications. Nanoparticles that show promise in two-dimensional cell culture systems often fail in more complex environments, possibly due to the lack of penetration in dense, three-dimensional structures. Multicellular tumor spheroids are an emerging model system to investigate interactions of nanoparticles with...
We report the construct of a nanosystem based on multi-walled carbon nanotubes (MWCNT) and the photosensitizer m-tetrahydroxyphenylchlorin (mTHPC) for cancer treatment by combination of photodynamic (PDT) and photothermal (PTT) therapy. The photoactivity of the complex mTHPC/MWCNT was studied revealing quenching of the photosensitizer associated to CNT and almost total release of the photosensitizer...
We have developed multi-componential nanomaterials that are based on folic acid (FA) and polyethylenimine-functionalized carbon nanohorn conjugates that encapsulate magnetite nanoparticles. The nanoconjugates were characterized using a variety of experimental setups, including dynamic light scattering, thermogravimetric analysis, Fourier transform infrared spectrometry, and ultraviolet–visible–near-infrared...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.