Purpose: The wind-sensitive giant interneurons (GIs) whose somata and dendritic processes are located in the terminal abdominal ganglion, play a role in directing wind-elicited escape behavior in the cricket, Gryllus bimaculatus. To visualize chemical computation in dendritic processing, we examined intracellular Ca 2 + change in GIs.Methods: After loading the fluorescent calcium indicator, Calcium Green 1, the fluorescent images of giant interneurons were recorded by a conforcal laser-scanning microscope.Results: Depolarization by current injection or electrical stimulation of cercal afferents caused fast Ca 2 + increase on dendritic sites of GIs. The amplitude and latency of Ca 2 + increase by ipsilateral cercal afferents stimulation were different from those of contralateral one.Conclusion: The spatio-temporal differences between Ca 2 + responses to ipsi- and contralateral cercal afferents stimulation indicate the importance of chemical computation in dendritic integration of synaptic inputs coding the wind signals.