In this paper, a mathematical model for the lactic acid fermentation in membrane bioreactor is investigated. Firstly, continuous input substrate is taken. The existence and local stability of two equilibria are studied. According to Poincare–Bendixson theorem, we obtain the condition for the globally asymptotical stability of the equilibria. Secondly, using the Floquet’s theorem and small-amplitude perturbation method, we obtain the biomass-free periodic solution is locally stable if R 2 <1. The permanent conditions of the system are also given. Finally, our findings are confirmed by means of numerical simulations.