Objectives: To study post-exercise facilitation following a non-fatigue exercise in a homogenous group of multiple sclerosis (MS) patients with complaints of muscle fatigue.Methods: In 15 MS patients and matched controls motor evoked potentials (MEP) were recorded from the biceps brachii muscle at time delays of 0.5-30s after an isometric contraction with a torque of 50% of maximal voluntary contraction (MVC) maintained for 2-6s. In addition, MEP was recorded after isometric torque of 25, 50, and 100% of MVC maintained for 6s.Results: Isometric non-fatigue contraction induced significant post-exercise increase in MEP amplitude in MS patients compared with controls being most pronounced after a contraction for 6s. The post-exercise increase in MEP lasted for longer than 30s in MS patients.Conclusions: Post-exercise increase of MEP amplitude following a non-fatigue exercise was significant in MS patients with complaints of muscle fatigue compared with healthy subjects.