Pure luteolin is a remarkably heat (200°C/6days) and UV stable UV-A screen, however, native luteolin enriched to 37% in an edelweiss extract lost its UV-A screen properties upon UV irradiation (∼4MJm −2 ). This contrasting behavior led to the examination of a series of purified luteolin derivatives as UV screen candidates. 3′,4′,5,7-Tetralipoyloxyflavones were synthesized from luteolin (3′,4′,5,7-tetrahydroxyflavone) and fatty acid chlorides. These acylated semi-biomolecules show a hypsochromic shift in UV–Vis spectra of about Δλ A→B =58nm and absorbed in the centre of the harmful UV-B band (λ max =295nm). Luteolin was also hydroxyethylated with Br(CH 2 ) 2 OH. This substitution has no effect on the λ max =330nm absorption of luteolin (UV-A band). Finally the natural 4′-O-β-glucosyl-3′,5,7-trihydroxyflavone was extracted from edelweiss and used as a purified natural benchmark. Glycosylated and hydroxyethylated luteolin are both UV stable. Fully acylated luteolin derivatives degrade upon UV exposure to a stable UV-C screen with a hypsochroic shift Δλ B→C =35nm. All in all, three molecular structures based on luteolin with sunscreen properties were found, distinguishable in: UV-A, UV-B, and UV-C filters. The natural product based UV-absorbers show promise as alternatives to synthetic molecules and nanoparticles in sunscreen products.