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Aim This paper compares the effects of MC903 (calcipotriol) and 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ; calcitriol] on differentiation and proliferation of normal human keratinocytes cultured in serum-free medium. In order to understand the inhibitory mechanism of MC903, we examined its effect on cell cycle kinetics and the phosphorylation of retinoblastoma gene product...
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