H 3 PMo 12 O 40 catalyst was chemically immobilized on the surface modified CMK-3 (SM-CMK-3) support as a charge compensating component, by taking advantage of the overall negative charge of [PMo 12 O 40 ] 3− . The supported H 3 PMo 12 O 40 /SM-CMK-3 catalyst was characterized to have high surface area (≈1000m 2 /g) and relatively large pore volume (0.83cm 3 /g). The H 3 PMo 12 O 40 /SM-CMK-3 catalyst was applied to the vapor-phase 2-propanol conversion reaction. The H 3 PMo 12 O 40 /SM-CMK-3 catalyst exhibited higher 2-propanol conversion than the unsupported H 3 PMo 12 O 40 and the impregnated H 3 PMo 12 O 40 on CMK-3. Furthermore, the PMo 12 /SM-CMK-3 catalyst showed the enhanced oxidation activity (acetone formation) and the suppressed acid catalytic activity (propylene formation) compared to the other two catalysts. It is believed that [PMo 12 O 40 ] 3− species were chemically and finely immobilized on the SM-CMK-3 support as charge matching species, and thus, the PMo 12 /SM-CMK-3 catalyst showed an excellent oxidation activity.