New physics effects through the direct CP violation and the decay rate change are investigated in the semileptonic D l 4 decays, D + /-->Kπl + /-ν, by including a scalar-exchange interaction with a complex coupling. In the decay process, we included various excited states as intermediate states decaying to the final hadrons, K+π, and found that among the intermediate states only the lowest state (K * ) is dominant and the other higher excited states are negligible, contrary to the B l 4 decays. We also obtained constraints on the new complex coupling within the multi-Higgs doublet model and the scalar leptoquark models.