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CD46, a membrane complement regulator, has been implicated as pathogen receptor, T cell activator and contributor to spermatozoa–egg interactions. In man, a role in the fertilization process was suggested by its localization on the acrosome. In rodents, CD46 is expressed only on the spermatozoal acrosome, suggesting an essential role at this site. This restricted expression led us to ask whether immunization...
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