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We assessed aging in continuous donor skin fibroblast cell line GGM5 up to the 25th passage by in vitro replicative senescence, telomere dynamics and chromosomal abnormalities. Cell proliferation rate increased from 0.84±0.26 (primary cells) to 1.20±0.17 (13–15 passage group) per day and reduced to 0.65±0.14 in 22–25 passages. Cell proliferation rate was reduced by 45.7% after 87.62 CPDs. Cell viability...
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