This study aims at exploring the bi-directional long run relationship between energy consumption, Carbon Dioxide emission, and economic growth in the Latin American and Caribbean countries. The Canonical Cointegrating Regression (CCR) is used to achieve the goal of this study taking the period of 1980–2008. The study arrived at different results. While 60% of the countries have a positive bi-directional long run relationship between energy consumption, Carbon Dioxide emission, and economic growth, the others have mixed results. The results of the study motivated the researcher to recommend that these countries should increase their energy efficiency, increase the share of green energy from their total energy use, and increase energy conservation in order to reduce unnecessary waste of energy.