It is reported for the first time that by adding the appropriate amounts of heavy-atom salts to glucose and trehalose, clear and rigid glasses can be obtained. Different percentages of NaI and TlNO 3 were used as heavy-atom salts. It was shown that both NaI and TlNO 3 reduced the room-temperature fluorescence (RTF), but enhanced the room-temperature phosphorescence (RTP) of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in glucose and trehalose glasses. Glucose and trehalose glasses with TlNO 3 shifted the position of the spectra of PhIP to longer wavelengths due to complex formation with thallium ion. However, NaI affected only the intensities of RTF and RTP signals of PhIP. The heavy-atom effect of NaI and TlNO 3 on 5,6-benzoquinoline (B[f]Q), 4-phenylphenol (4-PP), B(a)P-r-7,t-8,9,c-10-tetrahydrotetrol (tetrol I-1) and triphenylene in glucose glasses were also demonstrated. The limit of detection for PhIP and B[f]Q in glucose with 10% of NaI was 20 and 18 pg mg - 1 , respectively.