An isoperibolic micro-combustion calorimeter was designed, built and set up in our laboratory, taking as base a 1107 Parr combustion bomb of 22cm 3 of volume. Taken into account the geometrical form of the bomb, it was designed and constructed a vessel and a submarine chamber in brass. All of the pieces of the calorimeter were chromium-plated to reduce heat loss by radiation. The calorimeter was calibrated by using pellets of standard benzoic acid (mass approximate of 40mg) leading to the energy equivalent of ε(calor)=(1283.8±0.6)J·K −1 . In order to test the calorimeter, combustion experiments of salicylic acid were performed leading to a value of combustion energy of Δ c u ∘ =−(21,888.8±10.9)J·g −1 , which agrees with the reported literature values. The combustion of piperonylic acid was carried out as a further test leading to a value of combustion energy of Δ c u ∘ =−(20,215.9±10.4)J·g −1 in accordance with the reported literature value. The uncertainty of the calibration and the combustion of salicylic acid and piperonylic acid was 0.05%.