The effect of nicotine on peripheral cutaneous blood flow (CBF) was investigated in 83 volunteers consisting of 57 youths (20-47 y.o.), and 26 olds (50-76 y.o.) without cardiac disease. Each subject chewed nicotine gum (containing 2 mg nicotine) for 5-15 minutes, and CBF was measured by laser Doppler flowmetry at left 3rd finger, and temperature was measured by thermography. Increased CBF was observed in 31 among 57 youths (54%), and in 15 among 26 olds (56%). Elevated temperature was observed in 26 among 34 subjects (76%, mean, 0.56°C). A few findings on cardiovascular parameters have been obtained.Nicotine or nicotine derivertives could be useful agents for disorders of peripheral circulation.