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The antiviral activity of interferon-λ (IFN-λ) against several viruses has been reported, but it has not been investigated whether human IFN-λ can affect replication of the hepatitis B virus (HBV) in human hepatocyte-derived cells. We found that replication of HBV in a human hepatoma cell line was reduced by approximately 30% following treatment with a high concentration of IFN-λ. Furthermore, we...
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