Solid phase synthesis of a nucleic acid analog peptide (NAAP), as a substitute for antisense or triple-helix forming oligonucleotide, is described. The N-protected amino acid monomer was prepared starting from 3 -azido-3 -deoxythymidine (AZT) in 20 % overall yield. Condensation of the amino acid monomer was performed using Boc-chemistry on MBHA resin to afford a decapeptide containing 10 thymine bases in 21 % overall yield.