The aim of this work is the comparison of the drug release from tablets containing hydroxypropylcellulose as a binder (binder in powder form) and calcium sulphate as diluent and tablets without binder in order to examine the importance of the effect of the temperature. The results obtained were described and commented upon according to the laws of Weibull, Huguchi and Peppas. It was observed that the influence of temperature particularly at critical temperature on drug release from tablet prepared with HPC as binder, varies not only in function of the polymer concentration or polymer type but also in the behaviour of certain excipients used. This study has shown that the presence of calcium sulphate (water-soluble excipient) used as diluent allowed reduction of the temperature dependence at relatively high HPC concentration. This phenomenon is probably due to the concentration effect which acts on viscosity displacement of the critical temperature around 35-40°C. Thus the concentration factor and the presence of certain pharmaceutical excipients should be considered when using HPC in tablet form.