Single crystals of Ti- and Ni-doped enstatite MgSiO 3 were grown by the slow-cooling flux growth method. Acidic oxides such as V 2 O 5 , MoO 3 and lithium carbonate Li 2 CO 3 were used as fluxes. The starting mixture was first held at 950°C and then slowly cooled to 600°C at a rate of 1.8°C/h. Both Ti- and Ni-doped crystals were characterized and studied by stereo and polarized optical microscopy, powder crystal X-ray diffraction and scanning electron microscopy with energy-dispersive spectrometry. Some crystals were further characterized by single-crystal X-ray diffraction, Fourier transform infrared and cathodoluminescence. Doped enstatite consists mainly of aggregations of single crystals, and other phases were also detected in variable amounts in all the runs. Transparent Ti-doped enstatite (1.5–0.2mm in length) and green Ni-doped enstatite (0.6–0.2mm in length) single crystals were euhedral in form and not homogeneous in width. The effects of growth parameters on yield and size of crystals are also discussed.