We report on a case of a mesenteric cyst occurred in an 11-year-old girl referred to our institution after a period of 2 months of recurrent abdominal pain. The girl underwent laparoscopic surgery after abdominal Ultrasound Scan (US) and Magnetic Resonance Imaging (MRI) demonstrated a voluminous cyst of about 18 cm × 10.7 cm × 5.8 cm, occupying principally left abdomen. The cyst's root extended into retroperitoneum (Losanoff type 3) so the majority was excised and the remaining was marsupialized with good results. Laparoscopic excision of the mesenteric cyst has been facilitated by rolling the isolated cyst progressively around a grasper obtaining a constant control of the structure: the “spaghetti maneuver”. As confirmed by our experience, a mesenteric cyst can be easily and safely managed by laparoscopy, and the “spaghetti maneuver” is a feasible and effective surgical tool to facilitate the excision.