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The success of gene therapy relies on a safe and effective gene delivery system. In this communication, we describe the use of folate grafted PEI 600 –CyD (H 1 ) as an effective polyplex-forming plasmid delivery agent with low toxicity. The structures of the polymer and polyplex were characterized, and the in vitro transfection efficiency, cytotoxicity, and in vivo transfection of...
Poly(amidoamine)s with pendant primary amine (polymer 1a–1c) were evaluated as in vitro non-viral gene delivery vectors for bone marrow stromal cells (BMSCs). The cytotoxicity of these poly(amidoamine)s, measured by MTT assay, increased with increasing length of side chain, however, they were less toxic than branched polyethylenimine (PEI) 25kDa. Using pGL-3 and pEGFP-C1 as luciferase gene and green...
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