The toxicity of platinum(II) ion could be significantly modified by coordination with some organic compounds. In our study, the cytotoxicity and the influence of platinum(II) complexes, such as cisplatin, cis-[PtCl 2 (NH 3 ) 2 ], [PtCl 2 (SMC)] and [PtCl 2 (DMSO) 2 ] (where SMC is S-methyl-l-cysteine and DMSO is dimethyl sulphoxide) on spontaneous motility of isolated human fallopian tubes were investigated. Cisplatin showed potent pro-apoptotic effects on peripheral blood mononuclear cells (PBMC). However, peripheral blood mononuclear cells were substantially less sensitive to [PtCl 2 (SMC)] and [PtCl 2 (DMSO)], and these compounds showed no toxic effect on PBMC in all concentrations examined.Cisplatin showed concentration-dependent inhibition of spontaneous contractions of the isolated ampulla. (EC 50 =1.14±0.03×10 −6 M/l, r=0.714, p<0.05) while [PtCl 2 (SMC)] and [PtCl 2 (DMSO) 2 ] did not affect spontaneous contractions of isolated fallopian tube ampulla.