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Expression and phosphorylation of the cardiac Na + -Ca 2+ exchanger-1 (NCX-1) are up-regulated in heart failure (HF). We examined the effects of chronic cardiac contractility modulation (CCM) therapy on the expression and phosphorylation of NCX-1 and its regulators GATA-4 and FOG-2 in HF dogs.Studies were performed in LV tissue from 7 CCM-treated HF dogs, 7 untreated HF dogs, and 6...
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