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Dietary lipid content effects activation of peroxisome proliferator-activated receptor-α (PPAR-α) and may accelerate cardiac hypertrophy and dysfunction in response to pressure overload. This study investigated the effects of a high-fat diet on the development of cardiac hypertrophy.C57BL/6J mice (n = 14–16/group) underwent transverse aortic constriction (TAC) or sham surgery and were fed either standard...
It is not known how carbohydrate and fat intake affect the development of left ventricular (LV) hypertrophy and contractile dysfunction in response to pressure overload. We hypothesized that a low-carbohydrate/high-fat diet prevents LV hypertrophy and dysfunction compared with high-carbohydrate diets.Rats were fed high-carbohydrate diets composed of either starch or sucrose, or a low-carbohydrate/high-fat...
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