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The genetic modification of autoreactive memory T cells and autoimmune target cells to produce immunoregulatory cytokines and regenerative growth factors offers a promising new approach for the treatment of autoimmune disease.
Organ-specific autoimmunity is characterized by the accelerated loss of selected cell types, resulting in specific tissue destruction and disease. The role of different genetic or environmental factors in initiating the autoimmune reactivity is still unclear. However, novel mechanisms responsible for tissue destruction have recently been revealed. Here, Ruggero De Maria and Roberto Testi propose...
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