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In the psychosis prodrome, sub-threshold positive symptoms are often preceded by negative symptoms. Individuals exhibiting these attenuated symptoms are primarily adolescents and young adults at clinical high-risk (CHR) for developing a psychotic disorder. In the CHR state, negative symptoms are highly predictive of the transition to diagnosable illness, making the assessment of these symptoms very...
This study aimed to investigate the course of negative symptoms and its stability over a two-year period following a first-episode schizophrenia (FES) and the possible predictors of higher severity in this symptomatology after this period.In this longitudinal two-year prospective follow-up study we included 268 patients with a FES, according to DSM-IV. Analysis of variance was conducted in patients...
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