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Aflaxton B 1 rapidly inhibits RNA synthesis in rat liver cells, slices or liver in vivo. Established human cells lines (kidney T-cells, HeLa S 3 , Chang liver) and mouse fibroblast 3t3 are more slowly affected. Prolonged exposure of synchronized cell cultures to the agent show that cells are retarded in their passage through the S-phase and exhibit a decreased rate of DNA synthesis...
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