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When the phorbol ester, 4β-phorbol-12-myristate-13-acetate (PMA) or bacterial phospholipase C (PL-C) is added to a preparation of purified adult rat Leydig cells, containing 2 mM CaCl 2 , a time- and dose-dependent decrease of LH-stimulated testosterone production is observed. After a 3 h stimulation with oLH (100 ngml), PMA (100 ngml) and PL-C (1.6 Uml) do not affect the cell viability or...
We have studied the possible involvement of the activation of calcium-dependent phospholipid-activated protein kinase (PK-C) in the stimulatory action of LHRH on Leydig cells, using 4β-phorbol-12-myristate-13-acetate (PMA) and phospholipase C (PL-C). LHRH agonist (LHRH-A) and PL-C had a large synergistic effect on LH-stimulated steroid production, whereas PMA inhibited the effect of LH. However, PMA...
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