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The β-adrenergic receptor kinase (βARK) mediates agonist-dependent phosphorylation of the β 2 -adrenergic and related G protein-coupled receptors. A cDNA encoding bovine βARK has recently been isolated. In this work we have isolated a cDNA encoding human βARK from a retinal cDNA library. The cDNA encodes a protein of 689 amino acids with an overall 98.0% amino acid and 92.5% nucleotide identity...
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