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The hypothesis that the glucocorticoid hormone receptor interacts with RNA has been tested in cultured rat hepatoma cells. The receptor was covalently labeled with radioactive dexamethasone mesylate, and putative RNA-receptor complexes were stabilized by either cell-free crosslinking using formaldehyde or irradiation of intact cells. After chemical cross-linking in vitro, the receptor displayed the...
Steroid hormones are widely known to influence expression of the hormone-responsive genes in target cells. The action of steroid hormones is known to be mediated by their initial binding to specific 'receptor' proteins. The exact sequence of events, which follow hormone binding and lead to a cellular response, has remained unclear. This timely meeting has provided a forum for discussion of the recent...
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