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We have studied the biological properties of a new human CC chemokine, CKβ8, consisting of 99 amino acids including six cysteines. CKβ8 mRNA transcripts were induced in monocytes by IL-1β and, to a lesser extent, by IFNγ, and were detected in RNA extracted from normal human liver and gastrointestinal tract. CKβ8 is chemotactic for monocytes, but is inactive on IL-2 conditioned T lymphocytes, eosinophils...
The interaction of β-arrestin-1 with the somatostatin receptor type 2A (sst2A) was monitored using both biochemical and confocal imaging approaches. We show that, using transient transfection of either β-arrestin-1 or its dominant negative Δ-arrestin-1 in CHO cells stably transfected with the sst2A, β-arrestin-1 is colocalized with the receptor in endosomal vesicles after somatostatin-induced sequestration...
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