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Permeabilisation of PC12 cells with digitonin allowed a direct study of the intracellular action of botulinum neurotoxin A, one of a group of dichain proteins produced by Clostridium botulinum that causes the fatal neuroparalytic condition, botulism. Release of [ 3 H]noradrenaline from these permeabilised cells could be evoked by Ca 2+ and this was inhibited specifically by the...
The neurotoxin sensitivity of regulated exocytosis in the pancreatic acinar cell was investigated using streptolysin-O permeabilized pancreatic acini. Treatment of permeabilized acini with botulinum toxin B (BoNT/B) or botulinum toxin D (BoNT/D) had no detectable effect on Ca 2+ -dependent amylase secretion but did result in the complete cleavage of VAMP 2. In comparison, tetanus toxin...
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