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The immunosuppressant cyclosporin A (CsA) reduced the functional expression of Kir2.1 potassium channels in Xenopus oocytes in a dose-dependent manner with an IC 50 of 11 μM when the oocytes were incubated with CsA after RNA injection. FK506 was less effective than CsA; cyclosporin H, a non-immunosuppressive derivative of CsA, did not have a significant effect. CsA did not impair protein...
Fourier transform infrared (FTIR) spectroscopy was used to probe the secondary structure, orientation, and the kinetics of amide hydrogen-deuterium exchange (HX) of the small K + channel from Streptomyces lividans. Frequency component analysis of the amide I band showed that SKC1 is composed of 44-46% α-helix, 21-24% β-sheet, 10-12% turns and 18-20% unordered structures. The order parameter...
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