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Human serum transferrin (hTF) is a single-chain bilobal glycoprotein (80 kDa) which transports Fe 3+ and a variety of other metal ions in blood. Only diferric transferrin, not the apo-protein, binds strongly to transferrin receptors and is taken up by cells via receptor-mediated endocytosis. We show here that 2D [ 1 H, 13 C] NMR studies of recombinant ε-[ 1 ...
The effect of exogenous Fe-citrate complex (Fe doses of 120 and 240 μmol/kg) on nitric oxide (NO) production in vivo has been studied in blood and liver tissue of endotoxin-treated mice. Fe-citrate complex was administered to mice subcutaneously at the same time with intravenous injection of Escherichia coli lipopolysaccharide (LPS). Iron-dependent decrease in NO -2 /NO -3 ...
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