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Both estrogen receptor α (ERα) and the recently identified ERβ are nuclear receptors that are activated by estrogen. It was reported that ERα and ERβ form heterodimers. Here, we show that they activate transcription independently rather than synergistically via estrogen response elements (ERE). To show the cross-talk between ERα and ERβ, we utilized dominant negative mutants of ERs constructed by...
We investigated the presence and localization of oscillin in human spermatozoa in relation to the integrity of the sperm membrane, which was assessed by the hypo-osmotic swelling (HOS) test. We found no gross differences in the presence of oscillin in semen samples from men who presented with 70%, 40%, 25% or 2% of membrane-intact spermatozoa. By immunofluorescence, membrane-intact (HOS-positive)...
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