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Amyloid-beta peptide (Aβ) achieves neurodegeneration through unknown mechanisms. To elucidate some of these mechanisms, we conducted a cDNA subtraction analysis of Aβ-mediated neurotoxicity in neuronal cells and observed an up-regulation of the novel gene p17. The p17 protein was also found elevated in Alzheimer’s disease (AD) mouse model. Here, we characterised p17 primarily in cell lines with respect...
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