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The C-terminal region of adenovirus E1A interacts with the transcriptional corepressor, CtBP. The mechanism of transcriptional regulation by CtBP is not known. CtBP shares a significant homology with NAD + -dependent D2-hydroxy acid dehydrogenases. CtBP binds to NAD + and NADH. Both forms of the dinucleotide stimulate oligomerization of native CtBP and enhance complex formation with...
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