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The functional interaction of the voltage-gated potassium channel hKv1.5 with the PDZ domain containing protein SAP97 has been investigated. In marked contrast with the known dependence of SAP97-induced Kv1 potassium current down-regulation on the channel C-termini, SAP97 increased hKv1.5 current through an indirect interaction with the Kv1.5 N-terminus. Deletion of the Kv1.5 N-terminus eliminated...
Kvβ2 subunits associate with Kv1 and Kv4 K + channels, but the basis of preferential association is not understood. For example, detergent resistance suggests stronger auxiliary subunit association with Kv4.2 than with Kv1.2, but Kvβ2 preferentially localizes with the latter channels in brain. Here we examine the interaction of Kvβ2 with two native binding partners in brain: Kv4.3 and Kv1...
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