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The IQ motif is widely distributed in both myosins and non-myosins and is quite common in the database that includes more than 900 Pfam entries. An examination of IQ motif-containing proteins that are known to bind calmodulin (CaM) indicates a wide diversity of biological functions that parallel the Ca 2+ -dependent targets. These proteins include a variety of neuronal growth proteins,...
Ca 2+ -saturated calmodulin binds to double-length IQ lever-arm sequences from murine myosin-V, forming a 1:1 ''bridging'' complex with very high affinity, (K d <10 pM for double motifs, IQ34, IQ45 and IQ56). Such a 1:1 complex involves interaction of one calmodulin (CaM) molecule with two adjacent IQ-motifs, providing a molecular mechanism for the observed Ca 2+ ...
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