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The functional domain for candidacidal activity of bactenecin 5 has been determined by synthesizing bactenecin 5 and its fragments [1–22 (BN22), 7–22 (BN16) and 20–43 (BC24)]. The N-terminal sequence BN16 retained the candidacidal potency of the parent molecule and this region appears to be the candidacidal domain. The circular dichroism spectra of these peptides indicate the presence of largely poly-l-proline...
Novel cationic antimicrobial peptides, named nigrocin 1 and 2, were isolated from the skin of Rana nigromaculata and their amino acid sequences were determined. These peptides manifested a broad spectrum of antimicrobial activity against various microorganisms with different specificity. By primary structural analysis, it was revealed that nigrocin 1 has high sequence homology with brevinin 2 but...
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