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Cytokine receptor signaling involves the Jak/Stat pathways. Heterotrimeric IL-2R (α, β, γ c chains) activates Jak1 and Jak3, whereas homodimeric PRLR activates Jak2. The requirements directing such specificity of Jak activation are unknown. We show that chimeric receptors containing the intracellular domain of IL-2Rβ chain fused to the extracellular domain of either EPOR or Kit, a non-cytokine...
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