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PANDER is a cytokine co-secreted with insulin from islet β-cells. To date, the physiological function of PANDER remains largely unknown. Here we show that PANDER binds to the liver membrane by 125 I-PANDER saturation and competitive binding assays. In HepG2 cells, pre-treatment with PANDER ranging from 4pM to 4nM for 8h resulted in a maximal inhibition of insulin-stimulated activation of insulin...
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