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The main immunogenic region (MIR) of the acetylcholine receptor (AChR) is the target for the majority of high-affinity autoantibodies produced in myasthenia gravis patients. Some monoclonal antibodies (mAbs) to the MIR bind specifically, but with low affinity, to synthetic AChR α subunit peptides with the sequence α67-76. Studies of synthetic peptides suggest that amino acids α68 and α71 may be especially...
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